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The in vitro intestinal permeability results showed that the permeation of the drug from the microemulsion and SMEDDs was significantly higher than that obtained from the drug dispersion and marketed formulation.Conclusion : Lipid based formulations such as microemulsion and Self Microemulsifying drug delivery systems are expected to increase the oral bioavailability as evidenced by the increased intestinal permeation.To restore access and understand how to better interact with our site to avoid this in the future, please have your system administrator contact [email protected] If your browser does not accept cookies, you cannot view this site.J Pharm Bioall Sci 2011;2-8How to cite this URL: Thakkar H, Nangesh J, Parmar M, Patel D.J Pharm Bioall Sci [serial online] 2011 [cited 2017 Nov 16];2-8. 2011/3/3/442/84463 Delivery of active pharmaceutical ingredients through the oral route is the most preferred and convenient mode of drug administration.Allowing a website to create a cookie does not give that or any other site access to the rest of your computer, and only the site that created the cookie can read it.Correspondence Address: Hetal Thakkar Department of Pharmacy, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara India Source of Support: None, Conflict of Interest: None Background : Raloxifene, a second-generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women is administered orally in the form of a tablet.

Formulation and characterization of lipid-based drug delivery system of raloxifene-microemulsion and self-microemulsifying drug delivery system.

High first-pass hepatic metabolism is the major contributory factor responsible for inactivation of the drug before it reaches the systemic circulation.

Drugs administered orally are absorbed in the systemic circulation either via portal circulation or lymphatic transport.

SMEDDS is an isotropic mixture of oil, surfactant and co-surfactant, and drug substance; microemulsion can be generated rapidly upon gentle mixing with water or aqueous media.

Generally for oral preparation microemulsion preconcentrate (SMEDDS) is preferred over the regular microemulsion system because it will decrease the volume so it will become easy to fill in the soft gelatin capsule. Raloxifene is a second-generation SERM used to prevent osteoporosis in postmenopausal women.

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